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Enantioselective organocatalysis has emerged as a potent synthetic paradigm that complements metal-catalyzed reactions and has spurred the development of new ways to create chiral molecules of all shapes and sizes. Organocatalysis is an appealing approach for synthesising complicated structures because of its operational simplicity, ready availability of catalysts, and low toxicity. The impact of enamine, iminium, nucleophilic, and Brnsted acid catalysts in organic synthesis is discussed in this paper, as well as crucial strategic strategies for assembling useful compounds with high enantiomeric purity.
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