Mechanochemistry, which involves generating reactions by mechanical forces, can occasionally enable procedures that are difficult to achieve through classical solution synthesis. However, experts are still baffled as to how the process works on a molecular level. They haven't given up attempting to scale up mechanochemical processes, though. Reactive extrusion is a solvent-free polymer manufacturing technique that combines synthesis and shape into a single step. It's essentially solid-state flow chemistry, and it could help mechanochemical syntheses scale up. Chemists have already proved that screw extrusion can be used to create MOFs.
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